A randomized controlled trial
Click here to access the full studyPeter Munk Cardiac Centre, UHN & Lawrence S. Bloomberg Faculty of Nursing, University of Toronto
Toronto General Hospital, UHN
Lawrence S. Bloomberg Faculty of Nursing, University of Toronto
Toronto General Hospital, UHN
Toronto General Hospital, UHN
Toronto General Hospital, UHN
Toronto General Hospital, UHN
The total number of exclusions displayed here is not equal to the actual total number of participants not meeting the inclusion criteria (displayed in the CONSORT diagram), as some participants had multiple reasons for exlcusion.
Characteristic | High Flow nasal oxygen, N = 641 | Face mask oxygen, N = 651 |
Age (years) | 67 (14) | 70 (13) |
Gender | ||
Female | 19 (30%) | 17 (26%) |
Male | 45 (70%) | 47 (72%) |
Prefer not to say | 0 (0%) | 1 (1.5%) |
Other | 0 (0%) | 0 (0%) |
Smoking history | ||
Never | 23 (36%) | 25 (38%) |
Current | 7 (11%) | 7 (11%) |
Past | 34 (53%) | 33 (51%) |
Obstructive sleep apnea | 17 (27%) | 18 (28%) |
Uses CPAP | 9 (14%) | 12 (18%) |
Admission source | ||
Ward | 17 (27%) | 18 (28%) |
Day surgery | 45 (70%) | 44 (68%) |
CVICU | 2 (3.1%) | 3 (4.6%) |
CICU | 0 (0%) | 0 (0%) |
ASA classification status | ||
I | 0 (0%) | 0 (0%) |
II | 0 (0%) | 0 (0%) |
III | 21 (33%) | 16 (25%) |
IV | 43 (67%) | 49 (75%) |
Body mass index | 28.5 (5.1) | 28.8 (6.7) |
Procedure | ||
PPM | 11 (17%) | 17 (26%) |
PPM generator change | 6 (9.4%) | 7 (11%) |
PPM lead revision | 0 (0%) | 1 (1.5%) |
ICD | 19 (30%) | 13 (20%) |
ICD generator change | 10 (16%) | 13 (20%) |
ICD lead revision | 2 (3.1%) | 0 (0%) |
CRT-D | 11 (17%) | 11 (17%) |
CRT-P | 2 (3.1%) | 2 (3.1%) |
Wound revision | 0 (0%) | 0 (0%) |
Other | 3 (4.7%) | 1 (1.5%) |
Charlson Comorbidity Index | 4.46 (2.14) | 5.15 (2.51) |
Total dose of midazolam (mg) | 1.58 (0.84) | 1.45 (0.71) |
Total dose of propofol (mg) | 100 (126) | 88 (104) |
Total dose of fentanyl (mcg) | 71 (28) | 76 (56) |
1Statistics presented: mean (SD); n (%) | ||
Dotted lines display the time where 50% and 75% and 90% of procedures were completed
The average difference (95% credible intervals) in peak TcCO2 between groups was 0.0 mmHg (-1.3, 1.37).
The average difference (95% credible intervals) in mean TcCO2 between groups was -0.1 mmHg (-1.31, 1.14).
Dotted lines display the time where 50% and 75% and 90% of procedures were completed
| Subgroup analysis | ||||||
|---|---|---|---|---|---|---|
| Marginal posterior summaries of treatment effect when treatment is allowed to vary with stratification variables | ||||||
| Subgroup | Summary value | Peak TcCO2 | Treatment effect (95% CI) | Posterior probability | ||
| Face mask oxygen | High flow nasal oxygen | > 4 mmHg | < -4 mmHg | |||
| Baseline | N | 38 | 35 | |||
| mean (sd) | 49.0 mmHg (7.6) | 47.2 mmHg (6.3) | 0.7 mmHg (-0.98, 2.36) | 0.00 | 0.00 | |
| CRT | N | 9 | 9 | |||
| mean (sd) | 49.3 mmHg ( 5.6) | 50.3 mmHg (16.1) | 0.2 mmHg (-3.38, 4.14) | 0.03 | 0.01 | |
| OSA | N | 14 | 12 | |||
| mean (sd) | 48.0 mmHg (6.6) | 45.0 mmHg (5.9) | -2.4 mmHg (-5.49, 0.74) | 0.00 | 0.15 | |
Data shown here are for who experienced an oxygen desaturation event (defined as SpO2 <90%). Hover over a line to highlight a particular sequence.
Data shown here are for who experienced an oxygen desaturation event (defined as SpO2 <90%). Hover over a line to highlight a particular sequence.
Routinely collected SpO2 data were extracted from the Drug Reconciliation and Electronic Monitoring system for this outcome. Missing values at the beginning of these trajectories reflect the time prior to commencement of procedures when patients are getting prepared.
The treatment effect (95% credible intervals) was 1.2 (0.64, 2.17).
The treatment effect (95% credible intervals) was 0.3 (0.14, 0.83).
The treatment effect (95% credible intervals) was 0.1 (0.05, 0.31).
The treatment effect (95% credible intervals) was 0.0 (-0.33, 0.23).